- Lewis-Sigler Institute for Integrative Genomics
- Quantitative and Computational Biology
Advisors: A.J. te Velthuis and Ned Wingreen
te Velthuis and Wingreen Labs
I graduated from California Polytechnic State University SLO with a BS in Biochemistry and a minor in mathematics. Throughout the first two years of my undergraduate experience, I worked in an inorganic chemistry lab studying the impacts of metal complexes on DNA while attempting to develop a protocol to efficiently extract large cost-effective quantities of DNA from plant-based matter. The second half of my undergraduate career focused on computational modeling and molecular dynamics. I designed and published five computational models for activated human MEK1 as a tool to aid in drug design for cancers which arise from MEK1 protein irregularities.
I am jointly advised by Ned Wingreen and AJ te Velthuis and study the architecture and dynamics of viral genomes, including influenza, measles, and rabies. I utilize multiple microscopy techniques, including total internal reflection fluorescence (TIRF) microscopy and cryogenic transmission electron microscopy (Cryo-TEM), to visualize the structure and function of molecular complexes called ribonucleoproteins (RNPs) which encase viral genomes.
I am a Princeton Insights author and write short reviews on recently published Princeton University research in effort to make science more accessible. Check out our website: https://insights.princeton.edu
I am a My Green Lab Ambassador and strive to educate fellow colleagues on the importance of implementing more sustainable practices to do our part in minimizing unnecessary waste and energy consumption. For more information: https://www.mygreenlab.org
Sabsay, K. R.; Lee, R. T.; Ravatt, L. M.; Oza, J. P.; McDonald, A. R. Computational Models for Activated Human MEK1: Identification of Key Active Site Residues and Interactions. J. Chem. Inf. Model. 2019, acs.jcim.8b00989.