|Title||Junctions as organizing centers in epithelial cells? A fly perspective.|
|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Lecuit, T, Wieschaus, E|
|Date Published||2002 Feb|
|Keywords||Animals, Cell Adhesion, Cell Division, Cell Membrane, Drosophila, Epithelial Cells, Mitosis, Models, Biological|
Junctions isolate the apical from the basal-lateral surfaces and are required for the polarization of epithelial cells. Genetics of junction formation in Drosophila has identified numerous transmembrane and scaffolding proteins that assemble in membrane-associated complexes. This review focuses on recent findings suggesting that junctions are autonomous organizing centers for the establishment and maintenance of apical-basal polarity in epithelial cells as well as other polarized processes such as the orientation of the division apparatus.