|Title||Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Landis, JN, Murphy, CT|
|Date Published||2010 May|
|Keywords||Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Forkhead Transcription Factors, Organ Specificity, Signal Transduction, Transcription Factors|
In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output.
|Alternate Journal||Dev. Dyn.|