TitleIntegration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO.
Publication TypeJournal Article
Year of Publication2010
AuthorsLandis, JN, Murphy, CT
JournalDev Dyn
Date Published2010 May
KeywordsAnimals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Forkhead Transcription Factors, Organ Specificity, Signal Transduction, Transcription Factors

In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output.

Alternate JournalDev. Dyn.