Title | Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Landis, JN, Murphy, CT |
Journal | Dev Dyn |
Volume | 239 |
Issue | 5 |
Pagination | 1405-12 |
Date Published | 2010 May |
Keywords | Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Forkhead Transcription Factors, Organ Specificity, Signal Transduction, Transcription Factors |
Abstract | In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output. |
Alternate Journal | Dev. Dyn. |