TitleHow long does it take to establish a morphogen gradient?
Publication TypeJournal Article
Year of Publication2010
AuthorsBerezhkovskii, AM, Sample, C, Shvartsman, SY
JournalBiophys J
Date Published2010 Oct 20
KeywordsCell Differentiation, Diffusion, Dose-Response Relationship, Drug, Intercellular Signaling Peptides and Proteins, Kinetics, Models, Biological

A morphogen gradient is defined as a concentration field of a molecule that acts as a dose-dependent regulator of cell differentiation. One of the key questions in studies of morphogen gradients is whether they reach steady states on timescales relevant for developmental patterning. We propose a systematic approach for addressing this question and illustrate it by analyzing several models that account for diffusion and degradation of locally produced chemical signals.

Alternate JournalBiophys. J.