|Title||How long does it take to establish a morphogen gradient?|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Berezhkovskii, AM, Sample, C, Shvartsman, SY|
|Date Published||2010 Oct 20|
|Keywords||Cell Differentiation, Diffusion, Dose-Response Relationship, Drug, Intercellular Signaling Peptides and Proteins, Kinetics, Models, Biological|
A morphogen gradient is defined as a concentration field of a molecule that acts as a dose-dependent regulator of cell differentiation. One of the key questions in studies of morphogen gradients is whether they reach steady states on timescales relevant for developmental patterning. We propose a systematic approach for addressing this question and illustrate it by analyzing several models that account for diffusion and degradation of locally produced chemical signals.
|Alternate Journal||Biophys. J.|