Title | How long does it take to establish a morphogen gradient? |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Berezhkovskii, AM, Sample, C, Shvartsman, SY |
Journal | Biophys J |
Volume | 99 |
Issue | 8 |
Pagination | L59-61 |
Date Published | 2010 Oct 20 |
Keywords | Cell Differentiation, Diffusion, Dose-Response Relationship, Drug, Intercellular Signaling Peptides and Proteins, Kinetics, Models, Biological |
Abstract | A morphogen gradient is defined as a concentration field of a molecule that acts as a dose-dependent regulator of cell differentiation. One of the key questions in studies of morphogen gradients is whether they reach steady states on timescales relevant for developmental patterning. We propose a systematic approach for addressing this question and illustrate it by analyzing several models that account for diffusion and degradation of locally produced chemical signals. |
Alternate Journal | Biophys. J. |