TitleHow the Dorsal gradient works: insights from postgenome technologies.
Publication TypeJournal Article
Year of Publication2008
AuthorsHong, J-W, Hendrix, DA, Papatsenko, D, Levine, MS
JournalProc Natl Acad Sci U S A
Date Published2008 Dec 23
KeywordsAnimals, Body Patterning, Drosophila, Drosophila Proteins, Embryo, Nonmammalian, Embryonic Induction, Gene Expression Regulation, Developmental, Nuclear Proteins, Phosphoproteins, Transcription Factors

Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, we discuss how a gradient of the maternal transcription factor Dorsal produces complex patterns of gene expression across the dorsal-ventral (DV) axis of the early Drosophila embryo. The identification of 60-70 Dorsal target genes, along with the characterization of approximately 35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles.

Alternate JournalProc. Natl. Acad. Sci. U.S.A.