|Title||HOT DNAs: a novel class of developmental enhancers.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Farley, E, Levine, M|
|Date Published||2012 May 1|
|Keywords||Animals, Body Patterning, Drosophila melanogaster, Enhancer Elements, Genetic, Gene Expression Regulation, Developmental|
Enhancers mediate localized patterns of gene expression during development. A common feature of "traditional" enhancers is the presence of clustered binding motifs for sequence-specific transcription factors (TFs). In this issue of Genes & Development, Kvon and colleagues (pp. 908-913) present new evidence that HOT (highly occupied transcription) DNAs direct specific patterns of gene expression, despite being depleted for TF-binding motifs.
|Alternate Journal||Genes Dev.|