TitleHOT DNAs: a novel class of developmental enhancers.
Publication TypeJournal Article
Year of Publication2012
AuthorsFarley, E, Levine, M
JournalGenes Dev
Date Published2012 May 1
KeywordsAnimals, Body Patterning, Drosophila melanogaster, Enhancer Elements, Genetic, Gene Expression Regulation, Developmental

Enhancers mediate localized patterns of gene expression during development. A common feature of "traditional" enhancers is the presence of clustered binding motifs for sequence-specific transcription factors (TFs). In this issue of Genes & Development, Kvon and colleagues (pp. 908-913) present new evidence that HOT (highly occupied transcription) DNAs direct specific patterns of gene expression, despite being depleted for TF-binding motifs.

Alternate JournalGenes Dev.