TitleGrowth-induced instability in metabolic networks.
Publication TypeJournal Article
Year of Publication2007
AuthorsGoyal, S, Wingreen, NS
JournalPhys Rev Lett
Date Published2007 Mar 30
KeywordsAlgorithms, Biological Evolution, Cell Growth Processes, Cells, Feedback, Homeostasis, Kinetics

Product-feedback inhibition is a ubiquitous regulatory scheme for maintaining homeostasis in living cells. Individual metabolic pathways with product-feedback inhibition are stable as long as one pathway step is rate limiting. However, pathways are often coupled both by the use of a common substrate and by stoichiometric utilization of their products for cell growth. We show that such a coupled network with product-feedback inhibition may exhibit limit-cycle oscillations which arise via a Hopf bifurcation. Our results highlight novel evolutionary constraints on the architecture of metabolism.

Alternate JournalPhys. Rev. Lett.