A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.

Title	A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.
Publication Type	Journal Article
Year of Publication	2003
Authors	Ranade, K, Hinds, D, Hsiung, CAgnes, Chuang, L-M, Chang, M-S, Chen, Y-T, Pesich, R, Hebert, J, Chen, Y-DI, Dzau, V, Olshen, R, Curb, D, Botstein, D, Cox, DR, Risch, N
Journal	Am J Hypertens
Volume	16
Issue	2
Pagination	158-62
Date Published	2003 Feb
Keywords	Adult, Asian Continental Ancestry Group, China, Chromosome Mapping, Chromosomes, Human, Pair 10, Genetic Predisposition to Disease, Genome, Human, Humans, Hypertension, Japan, Lod Score, Middle Aged
Abstract	BACKGROUND: Our understanding of genes that predispose to essential hypertension is poor. METHODS: A genome-wide scan for linkage at approximately 10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). RESULTS: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. CONCLUSIONS: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population.
Alternate Journal	Am. J. Hypertens.