TitleA genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.
Publication TypeJournal Article
Year of Publication2003
AuthorsRanade, K, Hinds, D, Hsiung, CAgnes, Chuang, L-M, Chang, M-S, Chen, Y-T, Pesich, R, Hebert, J, Chen, Y-DI, Dzau, V, Olshen, R, Curb, D, Botstein, D, Cox, DR, Risch, N
JournalAm J Hypertens
Date Published2003 Feb
KeywordsAdult, Asian Continental Ancestry Group, China, Chromosome Mapping, Chromosomes, Human, Pair 10, Genetic Predisposition to Disease, Genome, Human, Humans, Hypertension, Japan, Lod Score, Middle Aged

BACKGROUND: Our understanding of genes that predispose to essential hypertension is poor.

METHODS: A genome-wide scan for linkage at approximately 10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580).

RESULTS: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5.

CONCLUSIONS: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population.

Alternate JournalAm. J. Hypertens.