TitleThe genetic basis of natural variation in mushroom body size in Drosophila melanogaster.
Publication TypeJournal Article
Year of Publication2015
AuthorsZwarts, L, Broeck, LVanden, Cappuyns, E, Ayroles, JF, Magwire, MM, Vulsteke, V, Clements, J, Mackay, TFC, Callaerts, P
JournalNat Commun
Date Published2015 Dec 11
KeywordsAnimals, Drosophila melanogaster, Drosophila Proteins, Gene Expression Regulation, Male, Mushroom Bodies, RNA Interference, Transcription Factors

Genetic variation in brain size may provide the basis for the evolution of the brain and complex behaviours. The genetic substrate and the selective pressures acting on brain size are poorly understood. Here we use the Drosophila Genetic Reference Panel to map polymorphic variants affecting natural variation in mushroom body morphology. We identify 139 genes and 39 transcription factors and confirm effects on development and adult plasticity. We show correlations between morphology and aggression, sleep and lifespan. We propose that natural variation in adult brain size is controlled by interaction of the environment with gene networks controlling development and plasticity.

Alternate JournalNat Commun
PubMed ID26656654
PubMed Central IDPMC4682101
Grant ListR01 GM045146 / GM / NIGMS NIH HHS / United States
R01 GM45146 / GM / NIGMS NIH HHS / United States
R01 GM076083 / GM / NIGMS NIH HHS / United States
R01 GM084947 / GM / NIGMS NIH HHS / United States
R01-GM084947 / GM / NIGMS NIH HHS / United States