Title | Formation of morphogen gradients: local accumulation time. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Berezhkovskii, AM, Sample, C, Shvartsman, SY |
Journal | Phys Rev E Stat Nonlin Soft Matter Phys |
Volume | 83 |
Issue | 5 Pt 1 |
Pagination | 051906 |
Date Published | 2011 May |
Keywords | Cell Differentiation, Diffusion, Gene Expression Regulation, Models, Biological, Time Factors |
Abstract | Spatial regulation of cell differentiation in embryos can be provided by morphogen gradients, which are defined as the concentration fields of molecules that control gene expression. For example, a cell can use its surface receptors to measure the local concentration of an extracellular ligand and convert this information into a corresponding change in its transcriptional state. We characterize the time needed to establish a steady-state gradient in problems with diffusion and degradation of locally produced chemical signals. A relaxation function is introduced to describe how the morphogen concentration profile approaches its steady state. This function is used to obtain a local accumulation time that provides a time scale that characterizes relaxation to steady state at an arbitrary position within the patterned field. To illustrate the approach we derive local accumulation times for a number of commonly used models of morphogen gradient formation. |
Alternate Journal | Phys Rev E Stat Nonlin Soft Matter Phys |