TitleFemale sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations.
Publication TypeJournal Article
Year of Publication1989
AuthorsSchupbach, T, Wieschaus, E
JournalGenetics
Volume121
Issue1
Pagination101-17
Date Published1989 Jan
KeywordsAnimals, Blastoderm, Chromosome Mapping, Chromosomes, Crosses, Genetic, Drosophila melanogaster, Ethyl Methanesulfonate, Female, Fertility, Gastrula, Genetic Complementation Test, Homozygote, Mutation, Oogenesis, Ovum, Phenotype, Zygote
Abstract

In mutagenesis screens for recessive female sterile mutations on the second chromosome of Drosophila melanogaster 529 chromosomes were isolated which allow the homozygous females to survive, but cause them to be sterile. In 136 of these lines, mutant females produce morphologically normal eggs which cannot support normal embryonic development. These "maternal-effect" mutations fall into 67 complementation groups which define 23 multiply hit and 44 singly hit loci. In eggs from 14 complementation groups development is blocked before the formation of a syncytial blastoderm. In eggs from 12 complementation groups development is abnormal before cellularization, 17 complementation groups cause abnormal cellularization, 12 complementation groups cause changes in cellular morphology in early gastrulation stages, and 12 complementation groups seem to affect later embryonic development.

Alternate JournalGenetics