Jan 29, 2024, 3:00 pm4:00 pm
101 Carl Icahn Lab


Event Description

Despite highly dynamic interactions between molecules in cells, most cell types maintain their distinctive homeostatic state and do not spontaneously convert to markedly different states. Understanding how cells accommodate the stochastic behavior of their constituent molecules to resist state changes is useful to understand how cell states can be converted in developmental, regenerative, and signal-responsive contexts.  Given that gene activity is a dominant parameter in cell state control, understanding how genes are kept silent, to resist cell state changes, and how gene silencing can be overcome, to undergo a state change, will provide insights that ultimately will enable us to control cell states at will. I will discuss ways that scanning of chromatin by pioneer transcription factors, which are distinguished by their nucleosome binding activity, can elicit global and specific changes in chromatin dynamics related to their ability to elicit changes in cell fate.

Event Category
QCB Seminar Series