TitleDynamics of maternal morphogen gradients in Drosophila.
Publication TypeJournal Article
Year of Publication2008
AuthorsShvartsman, SY, Coppey, M, Berezhkovskii, AM
JournalCurr Opin Genet Dev
Date Published2008 Aug
KeywordsAnimals, Body Patterning, Drosophila, Embryo, Nonmammalian, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Developmental, Insect Proteins, Models, Biological, Morphogenesis, Protein Transport, Signal Transduction

The first direct studies of morphogen gradients were done in the end of 1980s, in the early Drosophila embryo, which is patterned under the action of four maternally determined morphogens. Since the early studies of maternal morphogens were done with fixed embryos, they were viewed as relatively static signals. Several recent studies analyze dynamics of the anterior, dorsoventral, and terminal patterning signals. The results of these quantitative studies provide critical tests of classical models and reveal new modes of morphogen regulation and readout in one of the most extensively studied patterning systems.

Alternate JournalCurr. Opin. Genet. Dev.