TitleDominant negative regulation of the mouse alpha-fetoprotein gene in adult liver.
Publication TypeJournal Article
Year of Publication1990
AuthorsVacher, J, Tilghman, SM
JournalScience
Volume250
Issue4988
Pagination1732-5
Date Published1990 Dec 21
KeywordsAging, alpha-Fetoproteins, Animals, Animals, Newborn, Chromosome Deletion, Cloning, Molecular, DNA-Binding Proteins, Enhancer Elements, Genetic, Fetus, Gene Expression Regulation, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 1-beta, Liver, Mice, Nuclear Proteins, Transcription Factors, Transcription, Genetic
Abstract

Transcription of the mouse alpha-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation site of the alpha-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.
Alternate JournalScience