|Title||Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver.|
|Publication Type||Journal Article|
|Year of Publication||1990|
|Authors||Vacher, J, Tilghman, SM|
|Date Published||1990 Dec 21|
|Keywords||Aging, alpha-Fetoproteins, Animals, Animals, Newborn, Chromosome Deletion, Cloning, Molecular, DNA-Binding Proteins, Enhancer Elements, Genetic, Fetus, Gene Expression Regulation, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 1-beta, Liver, Mice, Nuclear Proteins, Transcription Factors, Transcription, Genetic|
Transcription of the mouse alpha-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation site of the alpha-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.