TitleThe Dlk1 and Gtl2 genes are linked and reciprocally imprinted.
Publication TypeJournal Article
Year of Publication2000
AuthorsSchmidt, JV, Matteson, PG, Jones, BK, Guan, XJ, Tilghman, SM
JournalGenes Dev
Date Published2000 Aug 15
KeywordsAnimals, Base Sequence, Chromosome Mapping, DNA Methylation, DNA Primers, Female, Gene Expression Regulation, Developmental, Genetic Linkage, Genomic Imprinting, Muridae, Peromyscus, Reverse Transcriptase Polymerase Chain Reaction

Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Gtl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.

Alternate JournalGenes Dev.