TitleDiscovery of biological networks from diverse functional genomic data.
Publication TypeJournal Article
Year of Publication2005
AuthorsMyers, CL, Robson, D, Wible, A, Hibbs, MA, Chiriac, C, Theesfeld, CL, Dolinski, K, Troyanskaya, OG
JournalGenome Biol
Date Published2005
KeywordsBayes Theorem, Cell Cycle Proteins, Computational Biology, Computer Graphics, Genomics, HSP90 Heat-Shock Proteins, Molecular Chaperones, Protein Interaction Mapping, Reproducibility of Results, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins

We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web.

Alternate JournalGenome Biol.