TitleDecoding cis-regulatory DNAs in the Drosophila genome.
Publication TypeJournal Article
Year of Publication2002
AuthorsMarkstein, M, Levine, M
JournalCurr Opin Genet Dev
Date Published2002 Oct
KeywordsAnimals, Binding Sites, Body Patterning, Computational Biology, Drosophila melanogaster, Genes, Insect, Genes, Regulator, Genome, Multigene Family, Promoter Regions, Genetic, Regulatory Sequences, Nucleic Acid, Transcription Factors, Transcription, Genetic

Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs are tedious. During the past year, computational methods have been used to identify novel cis-DNAs within the entire Drosophila genome. These methods change the way that cis-DNAs will be analyzed in future studies and offer the promise of unraveling complex gene networks.

Alternate JournalCurr. Opin. Genet. Dev.