TitleCoordinate regulation of an extended chromosome domain.
Publication TypeJournal Article
Year of Publication2003
AuthorsCalhoun, VC, Levine, M
JournalCell
Volume113
Issue3
Pagination278-80
Date Published2003 May 2
KeywordsAnimals, Chromosomes, Mammalian, Enhancer Elements, Genetic, Gene Expression Regulation, Developmental, Homeodomain Proteins, Mice, Promoter Regions, Genetic
Abstract

Spitz et al (2003[this issue of Cell]) describe the properties of a novel cis-regulatory DNA element, the global control region (GCR), which regulates gene expression over distances of several hundred kilobases at the mouse HoxD complex. The GCR provides an explanation for the colinear genetic linkage and expression of individual Hox genes within developing limbs.
Alternate JournalCell