|Title||Coordinate regulation of an extended chromosome domain.|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Calhoun, VC, Levine, M|
|Date Published||2003 May 2|
|Keywords||Animals, Chromosomes, Mammalian, Enhancer Elements, Genetic, Gene Expression Regulation, Developmental, Homeodomain Proteins, Mice, Promoter Regions, Genetic|
Spitz et al (2003[this issue of Cell]) describe the properties of a novel cis-regulatory DNA element, the global control region (GCR), which regulates gene expression over distances of several hundred kilobases at the mouse HoxD complex. The GCR provides an explanation for the colinear genetic linkage and expression of individual Hox genes within developing limbs.