TitleComparing whole genomes using DNA microarrays.
Publication TypeJournal Article
Year of Publication2008
AuthorsGresham, D, Dunham, MJ, Botstein, D
JournalNat Rev Genet
Date Published2008 Apr
KeywordsAnimals, Chromosome Mapping, Gene Dosage, Genetic Variation, Genome, Genomics, Humans, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide

The rapid accumulation of complete genomic sequences offers the opportunity to carry out an analysis of inter- and intra-individual genome variation within a species on a routine basis. Sequencing whole genomes requires resources that are currently beyond those of a single laboratory and therefore it is not a practical approach for resequencing hundreds of individual genomes. DNA microarrays present an alternative way to study differences between closely related genomes. Advances in microarray-based approaches have enabled the main forms of genomic variation (amplifications, deletions, insertions, rearrangements and base-pair changes) to be detected using techniques that are readily performed in individual laboratories using simple experimental approaches.

Alternate JournalNat. Rev. Genet.