|Title||Chemical sensing by nonequilibrium cooperative receptors.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Skoge, M, Naqvi, S, Meir, Y, Wingreen, NS|
|Journal||Phys Rev Lett|
|Date Published||2013 Jun 14|
Cooperativity arising from local interactions in equilibrium receptor systems provides gain, but does not increase sensory performance, as measured by the signal-to-noise ratio (SNR) due to a fundamental tradeoff between gain and intrinsic noise. Here we allow sensing to be a nonequilibrium process and show that energy dissipation cannot circumvent the fundamental tradeoff, so that the SNR is still optimal for independent receptors. For systems requiring high gain, nonequilibrium 2D-coupled receptors maximize the SNR, revealing a new design principle for biological sensors.
|Alternate Journal||Phys. Rev. Lett.|