Title | Chemical sensing by nonequilibrium cooperative receptors. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Skoge, M, Naqvi, S, Meir, Y, Wingreen, NS |
Journal | Phys Rev Lett |
Volume | 110 |
Issue | 24 |
Pagination | 248102 |
Date Published | 2013 Jun 14 |
Abstract | Cooperativity arising from local interactions in equilibrium receptor systems provides gain, but does not increase sensory performance, as measured by the signal-to-noise ratio (SNR) due to a fundamental tradeoff between gain and intrinsic noise. Here we allow sensing to be a nonequilibrium process and show that energy dissipation cannot circumvent the fundamental tradeoff, so that the SNR is still optimal for independent receptors. For systems requiring high gain, nonequilibrium 2D-coupled receptors maximize the SNR, revealing a new design principle for biological sensors. |
Alternate Journal | Phys. Rev. Lett. |