|Title||Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Yan, S-J, Zartman, JJ, Zhang, M, Scott, A, Shvartsman, SY, Li, WX|
|Journal||Mol Syst Biol|
|Keywords||Animals, Cell Differentiation, Drosophila, Drosophila Proteins, Feedback, Physiological, Fluorescent Antibody Technique, Receptor, Epidermal Growth Factor, Receptors, Invertebrate Peptide, Signal Transduction, Wing|
Cell differentiation in developing tissues is controlled by a small set of signaling pathways, which must coordinate the timing and levels of activation to ensure robust and precise outcomes. Highly coordinated activation of signaling pathways can result from cross-regulatory interactions in multi-pathway networks. Here we explore the dynamics and function of pathway coordination between the EGFR and DPP pathways during Drosophila wing-vein differentiation. We show that simultaneous activation of both the EGFR and DPP pathways must be maintained for vein cell differentiation and that above-threshold ectopic activation of either pathway is sufficient to drive vein cell differentiation outside the proveins. The joint activation of the EGFR and DPP signaling systems is ensured by a positive feedback loop, in which the two pathways stimulate each other at the level of ligand production.
|Alternate Journal||Mol. Syst. Biol.|