@article{2606,
  author = {Cholsoon Jang and Sheng Hui and Xianfeng Zeng and Alexis Cowan and Lin Wang and Li Chen and Raphael Morscher and Jorge Reyes and Christian Frezza and Ho Hwang and Akito Imai and Yoshiaki Saito and Keitaro Okamoto and Christine Vaspoli and Loewe Kasprenski and Gerald Zsido and Joseph Gorman and Robert Gorman and Joshua Rabinowitz},
  title = {Metabolite Exchange between Mammalian Organs Quantified in Pigs.},
  abstract = {<p>Mammalian organs continually exchange metabolites via circulation, but systems-level analysis of this shuttling process is lacking. Here, we compared, in fasted pigs, metabolite concentrations in arterial blood versus draining venous blood from 11 organs. Greater than 90\% of metabolites showed arterial-venous differences across at least one organ. Surprisingly, the liver and kidneys released not only glucose but also amino acids, both of which were consumed primarily by the intestine and pancreas. The liver and kidneys exhibited additional unexpected activities: liver preferentially burned unsaturated over more atherogenic saturated fatty acids, whereas the kidneys were unique in burning circulating citrate and net oxidizing lactate to pyruvate, thereby contributing to circulating redox homeostasis. Furthermore, we observed more than 700 other cases of tissue-specific metabolite production or consumption, such as release of nucleotides\&nbsp;by the spleen and TCA intermediates by\&nbsp;pancreas. These data constitute a high-value resource, providing a quantitative atlas of inter-organ metabolite exchange.</p>
},
  year = {2019},
  journal = {Cell Metab},
  volume = {30},
  pages = {594-606.e3},
  month = {09/2019},
  issn = {1932-7420},
  doi = {10.1016/j.cmet.2019.06.002},
  language = {eng},
}