@article{2460,
  author = {Noga Ron-Harel and Daniel Santos and Jonathan Ghergurovich and Peter Sage and Anita Reddy and Scott Lovitch and Noah Dephoure and Kyle Satterstrom and Michal Sheffer and Jessica Spinelli and Steven Gygi and Joshua Rabinowitz and Arlene Sharpe and Marcia Haigis},
  title = {Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.},
  abstract = {<p>Naive T\&nbsp;cell stimulation activates anabolic metabolism to fuel the transition from quiescence to growth and proliferation. Here we show that naive CD4(+) T\&nbsp;cell activation induces a unique program of mitochondrial biogenesis and remodeling. Using mass spectrometry, we quantified protein dynamics during T\&nbsp;cell activation. We identified substantial remodeling of the mitochondrial proteome over the first 24\&nbsp;hr of T\&nbsp;cell activation to generate mitochondria with a distinct metabolic signature, with one-carbon metabolism as the most induced pathway. Salvage pathways and mitochondrial one-carbon metabolism, fed by serine, contribute to purine and thymidine synthesis to enable T\&nbsp;cell proliferation and survival. Genetic inhibition of the mitochondrial serine catabolic enzyme SHMT2 impaired T\&nbsp;cell survival in culture and antigen-specific T\&nbsp;cell abundance in\&nbsp;vivo. Thus, during T\&nbsp;cell activation, mitochondrial proteome remodeling generates specialized mitochondria with enhanced one-carbon metabolism that is critical for T\&nbsp;cell activation and survival.</p>
},
  year = {2016},
  journal = {Cell Metab},
  volume = {24},
  pages = {104-17},
  month = {07/2016},
  issn = {1932-7420},
  doi = {10.1016/j.cmet.2016.06.007},
  language = {eng},
}