@article{2432,
  keywords = {Mutation, Saccharomyces cerevisiae, Cell Survival, Models, Biological, Fungal Proteins, Adaptor Proteins, Signal Transducing, Chromosome Aberrations, Nucleic Acid Hybridization, Saccharomyces cerevisiae Proteins, Genes, Lethal, Probability, Genes, Recessive, Gene Rearrangement, Base Pair Mismatch, Frameshift Mutation},
  author = {Julie Heck and David Gresham and David Botstein and Eric Alani},
  title = {Accumulation of recessive lethal mutations in Saccharomyces cerevisiae mlh1 mismatch repair mutants is not associated with gross chromosomal rearrangements.},
  abstract = {<p>We examined mismatch repair (MMR)-defective diploid strains of budding yeast grown for approximately 160 generations to determine whether decreases in spore viability due to the uncovering of recessive lethal mutations correlated with an increase in gross chromosomal rearrangements (GCRs). No GCRs were detected despite dramatic decreases in spore viability, suggesting that frameshift and/or other unrepaired DNA replication lesions play a greater role than chromosomal instability in decreasing viability in MMR-defective strains.</p>},
  year = {2006},
  journal = {Genetics},
  volume = {174},
  pages = {519-23},
  month = {09/2006},
  language = {eng},
}