@article{2298,
  keywords = {Animals, Immunoglobulin Heavy Chains, V(D)J Recombination},
  author = {Michael Levine},
  title = {The contraction of time and space in remote chromosomal interactions.},
  abstract = {<p>Lucas et al. report the visualization of V(D)J recombination of the immunoglobulin heavy-chain gene (Igh) in living pro-B cells. Despite the huge distances separating V coding sequences from D-J sequences (~2 Mb), the authors document an astonishingly rapid rate of remote associations. The key to speed is contraction of the Igh chromosomal domain. These findings provide a foundation for understanding long-range regulatory interactions in a variety of developmental processes, including the patterning of vertebrate limbs.</p>},
  year = {2014},
  journal = {Cell},
  volume = {158},
  pages = {243-4},
  month = {07/2014},
  language = {eng},
}