@article{2238, keywords = {Saccharomyces cerevisiae, Computational Biology, Genomics, Protein Interaction Mapping, Computer Graphics, Reproducibility of Results, Bayes Theorem, Saccharomyces cerevisiae Proteins, Cell Cycle Proteins, Molecular Chaperones, HSP90 Heat-Shock Proteins}, author = {Chad Myers and Drew Robson and Adam Wible and Matthew Hibbs and Camelia Chiriac and Chandra Theesfeld and Kara Dolinski and Olga Troyanskaya}, title = {Discovery of biological networks from diverse functional genomic data.}, abstract = {
We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web.
}, year = {2005}, journal = {Genome Biol}, volume = {6}, pages = {R114}, language = {eng}, }