@article{2073, keywords = {Humans, Chromosome Mapping, Genome, Human, Adult, Middle Aged, Genetic Predisposition to Disease, Asian Continental Ancestry Group, China, Hypertension, Japan, Chromosomes, Human, Pair 10, Lod Score}, author = {Koustubh Ranade and David Hinds and Chao Hsiung and Lee-Ming Chuang and Mau-Song Chang and Ying-Tsung Chen and Robert Pesich and Joan Hebert and Yii-Der Chen and Victor Dzau and Richard Olshen and David Curb and David Botstein and David Cox and Neil Risch}, title = {A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins.}, abstract = {
BACKGROUND: Our understanding of genes that predispose to essential hypertension is poor.
METHODS: A genome-wide scan for linkage at approximately 10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580).
RESULTS: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5.
CONCLUSIONS: We can exclude the possibility that a single gene accounts for at least 15\% of the variance in hypertension in this population.
}, year = {2003}, journal = {Am J Hypertens}, volume = {16}, pages = {158-62}, month = {02/2003}, language = {eng}, }