@article{2063,
  keywords = {Animals, Gene Expression Regulation, Developmental, Gene Expression Regulation, Gene Expression Profiling, Transcription Factors, Neurons, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Learning, Cyclic AMP Response Element-Binding Protein, Memory, Hippocampus, Memory, Long-Term},
  author = {Vanisha Lakhina and Rachel Arey and Rachel Kaletsky and Amanda Kauffman and Geneva Stein and William Keyes and Daniel Xu and Coleen Murphy},
  title = {Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs.},
  abstract = {<p>Induced CREB activity is a hallmark of long-term memory, but the full repertoire of CREB transcriptional targets required specifically for memory is not known in any system. To obtain a more complete picture of the mechanisms involved in memory, we combined memory training with genome-wide transcriptional analysis of C. elegans CREB mutants. This approach identified 757 significant CREB/memory-induced targets and confirmed the involvement of known memory genes from other organisms, but also suggested new mechanisms and novel components that may be conserved through mammals. CREB mediates distinct basal and memory transcriptional programs at least partially through spatial restriction of CREB activity: basal targets are regulated primarily in nonneuronal tissues, while memory targets are enriched for neuronal expression, emanating from CREB activity in AIM neurons. This suite of novel memory-associated genes will provide a platform for the discovery of orthologous mammalian long-term memory components.</p>},
  year = {2015},
  journal = {Neuron},
  volume = {85},
  pages = {330-45},
  month = {01/2015},
  language = {eng},
}