@article{2056, keywords = {Animals, Mice, Molecular Sequence Data, Evolution, Molecular, Gene Expression, Multigene Family, Amino Acid Sequence, Genomic Imprinting, Phylogeny, Sequence Homology, Placenta, Hybridization, Genetic, Peromyscus, Placental Lactogen}, author = {P Vrana and P Matteson and J Schmidt V and R Ingram and A Joyce and K Prince and M Dewey and S Tilghman}, title = {Genomic imprinting of a placental lactogen gene in Peromyscus.}, abstract = {

The mammalian genome contains over 30 genes whose expression is dependent upon their parent-of-origin. Of these imprinted genes the majority are involved in regulating the rate of fetal growth. In this report we show that in the deer mouse Peromyscusthe placental lactogen-1-variant ( pPl1-v) gene is paternally expressed throughout fetal development, whereas the linked and closely related pPl1gene is expressed in a biallelic manner. Neither the more distantly related pPl2Agene, nor the Mus Pl1gene displays any preferential expression of the paternal allele, suggesting that the acquisition of imprinting of pPl1-v is a relatively recent event in evolution. Although pPl1 expression is temporally mis-regulated in the dysplastic placentae of hybrids between two Peromyscus species, its over-expression cannot account for the aberrant phenotypes of these placentae. We argue that the species-specific imprinting of pPl1-v, encoding a growth factor that regulates nutrient transfer from mothers to their offspring, is consistent with the parent-offspring conflict model that has been proposed to explain the evolution of genomic imprinting.

}, year = {2001}, journal = {Dev Genes Evol}, volume = {211}, pages = {523-32}, month = {12/2001}, language = {eng}, }