@article{2009,
  keywords = {Humans, Gene Expression Profiling, Polymorphism, Single Nucleotide, Chromatin, Deoxyribonuclease I, Regulatory Elements, Transcriptional},
  author = {Troels Marstrand and John Storey},
  title = {Identifying and mapping cell-type-specific chromatin programming of gene expression.},
  abstract = {<p>A problem of substantial interest is to systematically map variation in chromatin structure to gene-expression regulation across conditions, environments, or differentiated cell types. We developed and applied a quantitative framework for determining the existence, strength, and type of relationship between high-resolution chromatin structure in terms of DNaseI hypersensitivity and genome-wide gene-expression levels in 20 diverse human cell types. We show that \~{}25\% of genes show cell-type-specific expression explained by alterations in chromatin structure. We find that distal regions of chromatin structure (e.g., {\textpm}200 kb) capture more genes with this relationship than local regions (e.g., {\textpm}2.5 kb), yet the local regions show a more pronounced effect. By exploiting variation across cell types, we were capable of pinpointing the most likely hypersensitive sites related to cell-type-specific expression, which we show have a range of contextual uses. This quantitative framework is likely applicable to other settings aimed at relating continuous genomic measurements to gene-expression variation.</p>},
  year = {2014},
  journal = {Proc Natl Acad Sci U S A},
  volume = {111},
  pages = {E645-54},
  month = {02/2014},
  language = {eng},
}