@article{1795,
  keywords = {In Situ Hybridization, Humans, Gene Expression Profiling, Oligonucleotide Array Sequence Analysis, Adenocarcinoma, Gastric Mucosa, Stomach Neoplasms, Gene Expression Regulation, Neoplastic, Reverse Transcriptase Polymerase Chain Reaction, DNA, Complementary, Life Tables, Neoplasm Proteins, Survival Analysis, Prognosis, Disease Progression, Enzyme Induction, Group II Phospholipases A2, Phospholipases A, Phospholipases A2},
  author = {Suet Leung and Xin Chen and Kent Chu and Siu Yuen and Jonathan Mathy and Jiafu Ji and Annie S Y Chan and Rui Li and Simon Law and Olga Troyanskaya and I-Ping Tu and John Wong and Samuel So and David Botstein and Patrick Brown},
  title = {Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis.},
  abstract = {<p>We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately equal 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.</p>},
  year = {2002},
  journal = {Proc Natl Acad Sci U S A},
  volume = {99},
  pages = {16203-8},
  month = {12/2002},
  language = {eng},
}