@article{1753,
  keywords = {Animals, Drosophila Proteins, Models, Biological, Drosophila melanogaster, Morphogenesis, Trans-Activators, Transcription Factors, Body Patterning, Recombinant Fusion Proteins, DNA-Binding Proteins, Cell Nucleus, Homeodomain Proteins, Reproducibility of Results, Hemoglobins, Mathematics},
  author = {Thomas Gregor and David Tank and Eric Wieschaus and William Bialek},
  title = {Probing the limits to positional information.},
  abstract = {<p>The reproducibility and precision of biological patterning is limited by the accuracy with which concentration profiles of morphogen molecules can be established and read out by their targets. We consider four measures of precision for the Bicoid morphogen in the Drosophila embryo: the concentration differences that distinguish neighboring cells, the limits set by the random arrival of Bicoid molecules at their targets (which depends on absolute concentration), the noise in readout of Bicoid by the activation of Hunchback, and the reproducibility of Bicoid concentration at corresponding positions in multiple embryos. We show, through a combination of different experiments, that all of these quantities are approximately 10\%. This agreement among different measures of accuracy indicates that the embryo is not faced with noisy input signals and readout mechanisms; rather, the system exerts precise control over absolute concentrations and responds reliably to small concentration differences, approaching the limits set by basic physical principles.</p>},
  year = {2007},
  journal = {Cell},
  volume = {130},
  pages = {153-64},
  month = {07/2007},
  language = {eng},
}