@article{1609,
  keywords = {Escherichia coli, Humans, Gene Expression Profiling, Gene Expression, Oligonucleotide Array Sequence Analysis, Bacteria, Bacterial Toxins, Bordetella pertussis, Dose-Response Relationship, Immunologic, Immunity, In Vitro Techniques, Leukocytes, Mononuclear, Lipopolysaccharides, Staphylococcus aureus, Virulence},
  author = {Jennifer Boldrick and Ash Alizadeh and Maximilian Diehn and Sandrine Dudoit and Chih Liu and Christopher Belcher and David Botstein and Louis Staudt and Patrick Brown and David Relman},
  title = {Stereotyped and specific gene expression programs in human innate immune responses to bacteria.},
  abstract = {<p>The innate immune response is crucial for defense against microbial pathogens. To investigate the molecular choreography of this response, we carried out a systematic examination of the gene expression program in human peripheral blood mononuclear cells responding to bacteria and bacterial products. We found a remarkably stereotyped program of gene expression induced by bacterial lipopolysaccharide and diverse killed bacteria. An intricately choreographed expression program devoted to communication between cells was a prominent feature of the response. Other features suggested a molecular program for commitment of antigen-presenting cells to antigens captured in the context of bacterial infection. Despite the striking similarities, there were qualitative and quantitative differences in the responses to different bacteria. Modulation of this host-response program by bacterial virulence mechanisms was an important source of variation in the response to different bacteria.</p>},
  year = {2002},
  journal = {Proc Natl Acad Sci U S A},
  volume = {99},
  pages = {972-7},
  month = {01/2002},
  language = {eng},
}