@article{1336, author = {Catherine Konopacki and Yuri Pritykin and Yury Rubtsov and Christina Leslie and Alexander Rudensky}, title = {Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function.}, abstract = {
Regulatory T cells (T cells), whose differentiation and function are controlled by transcription factor Foxp3, express the closely related family member Foxp1. Here we explored Foxp1 function in T cells. We found that a large number of Foxp3-bound genomic sites in T cells were occupied by Foxp1 in both T cells and conventional T cells (T cells). In T cells, Foxp1 markedly increased Foxp3 binding to these sites. Foxp1 deficiency in T cells resulted in their impaired function and competitive fitness, associated with markedly reduced CD25 expression and interleukin-2 (IL-2) responsiveness, diminished CTLA-4 expression and increased SATB1 expression. The characteristic expression patterns of CD25, Foxp3 and CTLA-4 in T cells were fully or partially rescued by strong IL-2 signaling. Our studies suggest that Foxp1 serves an essential non-redundant function in T cells by enforcing Foxp3-mediated regulation of gene expression and enabling efficient IL-2 signaling in these cells.
}, year = {2019}, journal = {Nature immunology}, volume = {20}, pages = {232-242}, month = {02/2019}, issn = {1529-2916}, doi = {10.1038/s41590-018-0291-z}, language = {eng}, }