TitleAutomatically tracking neurons in a moving and deforming brain.
Publication TypeJournal Article
Year of Publication2017
AuthorsNguyen, JP, Linder, AN, Plummer, GS, Shaevitz, JW, Leifer, AM
JournalPLoS Comput Biol
Volume13
Issue5
Paginatione1005517
Date Published2017 May
ISSN1553-7358
KeywordsAlgorithms, Animals, Brain, Caenorhabditis elegans, Cluster Analysis, Imaging, Three-Dimensional, Microscopy, Fluorescence, Neuroimaging, Neurons
Abstract

Advances in optical neuroimaging techniques now allow neural activity to be recorded with cellular resolution in awake and behaving animals. Brain motion in these recordings pose a unique challenge. The location of individual neurons must be tracked in 3D over time to accurately extract single neuron activity traces. Recordings from small invertebrates like C. elegans are especially challenging because they undergo very large brain motion and deformation during animal movement. Here we present an automated computer vision pipeline to reliably track populations of neurons with single neuron resolution in the brain of a freely moving C. elegans undergoing large motion and deformation. 3D volumetric fluorescent images of the animal's brain are straightened, aligned and registered, and the locations of neurons in the images are found via segmentation. Each neuron is then assigned an identity using a new time-independent machine-learning approach we call Neuron Registration Vector Encoding. In this approach, non-rigid point-set registration is used to match each segmented neuron in each volume with a set of reference volumes taken from throughout the recording. The way each neuron matches with the references defines a feature vector which is clustered to assign an identity to each neuron in each volume. Finally, thin-plate spline interpolation is used to correct errors in segmentation and check consistency of assigned identities. The Neuron Registration Vector Encoding approach proposed here is uniquely well suited for tracking neurons in brains undergoing large deformations. When applied to whole-brain calcium imaging recordings in freely moving C. elegans, this analysis pipeline located 156 neurons for the duration of an 8 minute recording and consistently found more neurons more quickly than manual or semi-automated approaches.

DOI10.1371/journal.pcbi.1005517
Alternate JournalPLoS Comput. Biol.
PubMed ID28545068
PubMed Central IDPMC5436637