TitleChemical Sensing by Nonequilibrium Cooperative Receptors.
Publication TypeJournal Article
Year of Publication2013
AuthorsSkoge, M, Naqvi, S, Meir, Y, Wingreen, NS
JournalPhys Rev Lett
Volume110
Issue24
Date Published2013 Jun 14
Abstract

Cooperativity arising from local interactions in equilibrium receptor systems provides gain, but does not increase sensory performance, as measured by the signal-to-noise ratio (SNR) due to a fundamental tradeoff between gain and intrinsic noise. Here we allow sensing to be a nonequilibrium process and show that energy dissipation cannot circumvent the fundamental tradeoff, so that the SNR is still optimal for independent receptors. For systems requiring high gain, nonequilibrium 2D-coupled receptors maximize the SNR, revealing a new design principle for biological sensors.

Alternate JournalPhys. Rev. Lett.